We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients.Twenty HIV-1 infected individuals were followed CURVED PANYLINERS for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and Accent Mirror CD4+ cell counts.Individuals with optimal response, i.e.
durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls.Individuals with non-optimal HIV-1 control did not restore their EBV control.Long-lasting suppression of HIV-replication after early initiation of cART is a prerequisite for re-establishing the immune control of EBV.